Publications

2024

TGFβ2-Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions

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Su-Jeong Oh*, Ye Young Shin*, Ji-Su Ahn, Hee-Jeong Park, Min-Jung Kang, Tae-Hoon Shin, Byung-Chul Lee, Won Kyu Kim, Jung-Min Oh, Dongjun Lee, Yun Hak Kim, Ji Min Kim, Eui-Suk Sung, Eun-Woo Lee, Jee-Heon Jeong, Byung-Joo Lee†, Yoojin Seo†, and Hyung-Sik Kim†

Advanced Science11(47):e2400660 (2024)
Sustained release of stem cell secretome from nano-villi chitosan microspheres for effective treatment of atopic dermatitis

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Su-Jeong Oh*, Tiep Tien Nguyen*, Yoojin Seo*, Hee-Jeong Park, Ji-Su Ahn, Ye Young Shin, Byung-Jae Kang, Min Jang, Junhyeung Park, Jee-Heon Jeong†, Hyung-Sik Kim†

Int J Biol Macromol 277(Pt4):134344 (2024)
Navigating the Landscape of Intestinal Regeneration: A Spotlight on Quiescence Regulation and Fetal Reprogramming

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Su-Jeong Oh, Yoojin Seo†, Hyung-Sik Kim†

Int J Stem Cells 17(3):213-223 (2024)
Endogenous stem cell mobilization and localized immunosuppression synergistically ameliorate DSS-induced Colitis in mice

Shobha Regmi, Shiva Pathak, Dinesh Chaudhary, Jong Oh Kim, Joo‑Won Nam, Hyung‑Sik Kim, Hu‑Lin Jiang, Dongryeol Ryu, Jong‑Hyuk Sung†, Simmyung Yook† and Jee‑Heon Jeong†

Stem Cell Research & Therapy 15(1):167 1-10 (2024)
Forsythia velutina Nakai extract: A promising therapeutic option for atopic dermatitis through multiple cell type modulation

Yujin Kwon*, Yoon Jin Kang*, Jaeyoung Kwon*, Su-Yeon Cho, Jiyoon Kim, Tam Thi Le, Hoseong Hwang, Barsha Deshar, Myungjun Kim, Ju Yeong Kim, Jae Hung Jung, Hyung-Sik Kim, Sang Hoon Jung†, Hak Cheol Kwon†, Won Kyu Kim†

Allergy 79(5):1242-1257 (2024)
Melatonin alleviates myocardial dysfunction through inhibition of endothelial-to-mesenchymal transition via the NF-κB pathway

Ran Kim*, Minsuk Kim*, Seongtae Jeong*, Sejin Kim, Hanbyeol Moon, Hojin Kim, Min Young Lee, Jongmin Kim, Hyung-Sik Kim, Murim Choi, Kunyoo Shin, Byeong-Wook Song†, Woochul Chang†

J Pineal Res 76(4):e12958 (2024)
Characterization of 3D Organotypic Culture of Mouse Adipose-Derived Stem Cells

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Tae Gen Son*, Yoojin Seo*, Won-Tae Kim, Meesun Kim, Seon Jeong Choi, Si Ho Choi, Byung-Jun Sung, Jae-Seok Min, Eon Chul Han, Hyung-Sik Kim

Int J Mol Sci 25(7):3931 (2024)

2023

Water Extract of Desalted Salicornia europaea Inhibits RANKL-Induced Osteoclast Differentiation and Prevents Bone Loss in Ovariectomized Mice

Ah-Ra Jang*, Yun-Ji Lee*, Dong-Yeon Kim, Tae-Sung Lee, Do-Hyeon Jung, Yeong-Jun Kim, In-Su Seo, Jae-Hun Ahn, Eun-Jung Song, Jisu Oh, Aoding Li, SiHoon Song, Hyung-Sik Kim, Min-Jung Kang, Yoojin Seo, Jeong-Yong Cho† and Jong-Hwan Park†

Nutrients 15(23):4968 (2023)
Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT

Yujin Kwon*, Jiyoon Kim*, Su-Yeon Cho, Yoon Jin Kang, Jongsoo Lee, Jaeyoung Kwon, Hyungjin Rhee, Sebastian Bauer, Hyung-Sik Kim, Esak Lee, Han Sang Kim, Jae Hung Jung, Hoguen Kim & Won Kyu Kim

Cell Death Differ 30(10):2309-2321 (2023)
Diagnostic potential of serum miR-532-3p as a circulating biomarker for experimental intrinsic drug-induced liver injury by acetaminophen and cisplatin in rats

Da-Bin Hwang*, Yoojin Seo*, Eunji Lee, Dong-Hoon Won, Changuk Kim, MinHwa Kang, Young Jeon, Hyung-Sik Kim, Jun Won Park, Jun-Won Yun*

Food Chem Toxicol 178:113890 (2023)
Predicting prognosis through the discovery of specific biomarkers according to colorectal cancer lymph node metastasis

Sung Won Park*, Junho Kang*, Hyung-Sik Kim, Sik Yoon, Byoung Soo Kim, Chaeseong Lim, Dongjun Lee, Yun Hak Kim

Am J Cancer Res 13(7):3221-3233 (2023)
Scalable and Uniform Fabrication of Dexamethasone-Eluting Depot-Engineered Stem Cell Spheroids as a Microtissue Construct to Target Bone Regeneration

Tiep Tien Nguyen*, Mai Thi Phuong*, Manju Shrestha*, Junhyeung Park, Pham Le Minh, Jong Oh Kim, Hyukjae Choi, Joo-Won Nam, Hu-Lin Jiang, Hyung-Sik Kim, Jee-Heon Jeong†, Jun-Beom Park†, Simmyung Yook†

ACS Appl Mater Interfaces 15(22):26373-26384 (2023)
METTL3 regulates alternative splicing of cell cycle-related genes via crosstalk between mRNA m6A modifications and splicing factors

Yeongjoo Kim*, Seungjae Shin*, Sunyoung Kwon*, Kisung Moon, Su-Vin Baek, Ahyoung Jo, Hyung-Sik Kim, Gue-Ho Hwang, Sangsu Bae, Yun Hak Kim†, Sung-Yup Cho†, Jung-Min Oh†

Am J Cancer Res 13(4):1443-1456 (2023)
Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats

Yong-Il Cheon*, Ji Min Kim*, Sung-Chan Shin, Hyung-Sik Kim, Jin-Choon Lee, Gi Cheol Park, Eui-Suk Sung, Minhyung Lee, Byung-Joo Lee

Aging-US 15(7):2418–2432 (2023)
Formulation of secretome derived from mesenchymal stem cells for inflammatory skin diseases

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Yoojin Seo*, Tiep Tien Nguyen*, Su-Jeong Oh*, Jee-Heon Jeong†, Hyung-Sik Kim†

J Pharm Invest 235–248 (2023)
Global prevalence of suicide by latitude: A systematic review and meta-analysis

Seongjun An*, Sungju Lim*, Hyun-Woo Kim, Hyung-Sik Kim, Dongjun Lee, Eunjeong Son, Tae Woo Kim, Tae Sik Goh, Kihun Kim†, Yun Hak Kim†

Asian J Psychiatr 81:103454 (2023)
Novel endogenous endoplasmic reticulum transmembrane protein SURF4 suppresses cell death by negatively regulating the STING-STAT6 axis in myeloid leukemia

Jayoung Kim*, Hansong Lee*, Chae Mi Hong, Ji Ho Nam, Hye Ju Yeo, Woo Hyun Cho, Hyung-Sik Kim, Changwan Hong, Yun Hak Kim†, Dongjun Lee†

Cancer Commun 43(3):395-399 (2023)
Intestinal organoids as advanced modeling platforms to study the role of host-microbiome interaction in homeostasis and disease

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Ji-Su Ahn*, Min-Jung Kang*, Yoojin Seo†, Hyung-Sik Kim†

BMB Reports 56(1):15-23 (2023)

2022

Risk stratification of patients with right-sided colorectal cancer based on the tumor-infiltrating M1 macrophage

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Dong Min Lim*, Junho Kang*, Soo-Yeon Woo, Hee-Sun Choi, Munju Kwon, Jayoung Kim, Hae Ryoun Park, Keehoon Jung, Ninib Baryawno†, Hyung-Sik Kim†, Dongjun Lee†, Yun Hak Kim†

Am J Cancer Res 12(12):5532-5551 (2022)
Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats

Ji-Min Kim, Sung-Chan Shin, Yong-Il Cheon, Hyung-Sik Kim, Gi-Cheol Park, Hyoung-Kyu Kim, Jin Han, Jung-Eun Seol, Elena A Vasileva, Natalia P Mishchenko, Sergey A Fedoreyev, Valentin A Stonik, Byung-Joo Lee

Mar Drugs 20(12):729 (2022)
Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium

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Ji-Su Ahn, Ye Young Shin, Su-Jeong Oh, Min-Hye Song, Min-Jung Kang, So Yeong Park, Phuong Thao Nguyen, Dang Khoa Nguyen, Hyoung Kyu Kim, Jin Han, Elena A Vasileva, Natalia P Mishchenko, Sergey A Fedoreyev, Valentin A Stonik, Yoojin Seo, Byung-Chul Lee†, Hyung-Sik Kim†

Mar Drugs 20(11):715 (2022)
ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19

Gi Cheol Park, Soo-Young Bang, Hyoun Wook Lee, Kyung Un Choi, Ji Min Kim, Sung-Chan Shin, Yong-Il Cheon, Eui-Suk Sung, Minhyung Lee, Jin-Choon Lee, Hyung-Sik Kim, Byung-Joo Lee

Oral Dis 28 Suppl 2:2456-2464 (2022)
Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines

Soo-Yeon Woo*, Hansong Lee*, Su Min Park, Hee-Seon Choi, Jayoung Kim, Munju Kwon, Jihyung Sohn, Ji Ho Nam, Hyung-Sik Kim, Parkyong Song, Ninib Baryawno, Yun-Hak Kim†, Koanhoi Kim†, Dongjun Lee†

Cell Death Dis 13(10):916 (2022)
CD82 attenuates TGF-β1-mediated epithelial-mesenchymal transition by blocking smad-dependent signaling in ARPE-19 cells

Hyesook Lee*, Jung-Hwa Han*, Yun Jeong Kang, Hyun Hwangbo, Aeseon Yoon, Hyung-Sik Kim, Dongjun Lee, Soo Yong Lee, Byung Hyun Choi, Jae-Joon Kim, Seo Rin Kim, Yung Hyun Choi†, Jin Hur†

Front Pharmacol 13:991056 (2022)
Association between Four Dietary Patterns and the Risk of Periodontal Diseases: A Systematic Review and Meta-Analysis

Jaehun Jeong, Hyung-Sik Kim, Dongjun Lee, Kihun Kim†, Yun-Hak Kim†

Nutrients 14(20):4362 (2022)
Mesenchymal stem cells target microglia via galectin-1 production to rescue aged mice from olfactory dysfunction

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Yoojin Seo*, Ji-Su Ahn*, Ye Young Shin, Su-Jeong Oh, Min-Hye Song, Min-Jung Kang, Jung-Min Oh, Dongjun Lee, Yun Hak Kim, Byung-Chul Lee, Tae-Hoon Shin†, Hyung-Sik Kim†

Biomed Pharmacother 153:113347 (2022)
Engineering of hybrid spheroids of mesenchymal stem cells and drug depots for immunomodulating effect in islet xenotransplantation

Tiep Tien Nguyen, Duc-Vinh Pham, Junhyeung Park, Cao Dai Phung, Mahesh Raj Nepal, Mahesh Pandit, Manju Shrestha, Youlim Son, Mili Joshi, Tae Cheon Jeong, Pil-Hoon Park, Dong-Young Choi, Jae-Hoon Chang, Ju-Hyun Kim, Jae-Ryong Kim, Il-Kug Kim, Chul Soon Yong, Jong Oh Kim, Jong-Hyuk Sung, Hu-Lin Jiang, Hyung-Sik Kim, Simmyung Yook†, Jee-Heon Jeong†

Sci Adv 8(34):eabn8614 (2022)
Oxime derivative TFOBO promotes cell death by modulating reactive oxygen species and regulating NADPH oxidase activity in myeloid leukemia

Ahyoung Jo*, Jae-Hwan Kwak*, Soo-Yeon Woo*, Bo-Young Kim, Yonghae Son, Hee-Seon Choi, Jayoung Kim, Munju Kwon, Hyok-Rae Cho, Seong-Kug Eo, Ji Ho Nam, Hyung-Sik Kim, Ninib Baryawno†, Dongjun Lee†, Koanhoi Kim†

Sci Rep 12(1):7519 (2022)
Microbial and molecular differences according to the location of head and neck cancers

Yun Kyeong Kim*, Eun Jung Kwon*, Yeuni Yu, Jayoung Kim, Soo-Yeon Woo, Hee-Sun Choi, Munju Kwon, Keehoon Jung, Hyung-Sik Kim, Hae Ryoun Park, Dongjun Lee†, Yun Hak Kim†

Cancer Cell Int 22(1):135 (2022)
Emerging organoid-based platforms to study salivary gland hypofunction

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Yoojin Seo, Hyung-Sik Kim

Organoid 2:e2 (2022)
Tonsil mesenchymal stem cells-derived extracellular vesicles prevent submandibular gland dysfunction in ovariectomized rats

Ji Min Kim, Jeong Hun Kim, Keunyoung Kim, Sung-Chan Shin, Yong-Il Cheon, Hyung Sik Kim, Jin-Choon Lee, Eui-Suk Sung, Minhyung Lee, Gi-Cheol Park, Byung-Joo Lee

Aging-US 14(5) (2022)
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics

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Ye Young Shin, Yoojin Seo, Su-Jeong Oh, Ji-Su Ahn, Min-Hye Song, Min-Jung Kang, Jung-Min Oh, Dongjun Lee, Yun Hak Kim, Eui-Suk Sung†, Hyung-Sik Kim†

J Pineal Res 72(1) (2022)

2021

Effects of oligonol on the submandibular gland in ovariectomized rats

Jeong Hun Kim, Hyangkyu Lee, Ji Min Kim, Hyung-Sik Kim, Sung-Chan Shin, Sun-Kyung Hwang, Byung-Joo Lee, Keunyoung Kim

Biomed Pharmacother. 141:111897 (2021)
Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPARγ pathway

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Ji-Su Ahn, Ji Won Yang, Su-Jeong Oh, Ye Young Shin, Min-Jung Kang, Hae Ryoun Park, Yoojin Seo, Hyung-Sik Kim

BMB Rep. 54(6):323-328 (2021)
Superoxide Dismutase 3-Transduced Mesenchymal Stem Cells Preserve Epithelial Tight Junction Barrier in Murine Colitis and Attenuate Inflammatory Damage in Epithelial Organoids

Lee-Jung Tak, Hae-Young Kim, Won-Kook Ham, Gaurav Agrahari, Yoojin Seo, Ji Won Yang, Eun-Joo An, Chul Hwan Bang, Min Jung Lee, Hyung-Sik Kim, Tae-Yoon Kim

Int J Mol Sci. 22(12):6431 (2021)
Heterospheroid formation improves therapeutic efficacy of mesenchymal stem cells in murine colitis through immunomodulation and epithelial regeneration

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Shobha Regmi, Yoojin Seo, Ji-Su Ahn, Shiva Pathak, Suman Acharya, Tiep Tien Nguyen, Simmyung Yook, Jong-Hyuk Sung, Jun-Beom Park, Jong Oh Kim, Chul Soon Young, Hyung-Sik Kim, Jee-Heon Jeong

Biomaterials. 271:120752 (2021)
Strategies to Potentiate Paracrine Therapeutic Efficacy of Mesenchymal Stem Cells in Inflammatory Diseases

Yoojin Seo, Min-Jung Kang, Hyung-Sik Kim

Int J Mol Sci. 22(7):3397 (2021)