Research I
Research I
Fetal-like Reversion and Intestinal Regeneration
The objective of this project is to establish an organoid-based platform to evaluate tissue regeneration using intestinal epithelial cells from various species, including humans, dogs, and mice. Moreover, the project aims to identify a new population of stem cells known as Revival Stem Cells (RSCs), which have been recently reported to drive regeneration after tissue damage in various diseases. By elucidating the mechanisms that induce these stem cells, the ultimate objective is to develop novel tissue regeneration strategies that could be applied to the treatment of damaged conditions, such as inflammatory bowel disease (IBD).
사람, 개, 마우스를 비롯한 다양한 종의 장 상피 오가노이드 기반 조직 재생 평가 플랫폼을 확립하고 질병으로 인한 조직 손상 후 재생을 주도하는 것으로 알려진 새로운 줄기세포인 재건 줄기세포 (Revival Stem Cell, RSC) 집단을 발굴하고 해당 줄기세포의 유도 기전을 규명하여 염증성장질환 등의 치료에 활용가능한 신개념 조직 재생 치료기술율 개발하고자 함
